Essay on Gamma HydroxyButyrate (GHB)

This essay has a total of 1327 words and 7 pages.

Gamma HydroxyButyrate (GHB)


GHB, or Gamma-Hydroxy Butyric Acid is an intoxicating chemical with medical, recreational,
and potentially entheogenic uses. It is a normal component of mammalian metabolism. It is
naturally found in every cell in the human body and is most properly considered a
nutrient. It is believed to be a neurotransmitter, although it is still unknown as to
whether it exhibits all of the properties required to be considered one.


GHB was first synthesized about thirty years ago by Dr. H. Laborit. He was a French
researcher interested in exploring the effects of GABA (gamma-aminobutyric acid) in the
brain. Over the years many researchers have studied GHB’s effects. In Europe it is used as
a general anesthetic, a treatment for insomnia and narcolepsy, an aid to childbirth, a
treatment for alcoholism and alcohol withdrawal syndrome and many other things. During the
1980's it was available over the counter for its ability to stimulate growth hormone
release which aids in fat reduction and muscle building. Now it is very popular as a
recreational drug due to its pleasant alcohol-like hangover- free high and strong sexual
effects. Some street terms include Liquid X, Liquid Ecstacy, Georgia Home Boy, Grievous
Bodily Harm, and Scoop. GHB is not approved in the US and has been banned from
over-the-counter sale by the FDA (1990). GHB has not yet been scheduled as a controlled
substance by the DEA, and therefore simple possession is not illegal. GHB continues to be
sold to legitimate laboratories and scientists for research purposes but selling it
specifically for human consumption, especially while making claims about its health
benefits, is a violation of current FDA regulations and policy. In some European
countries, GHB is an approved drug available by prescription. The Federal control may have
been an act to protect the pharmaceutical industry from competition from a safer, more
effective and less expensive alternative to sleeping pills.


There are many side effects and concerns associated with this drug. GHB affects the
release of dopamine in the brain, usually causing effects ranging from relaxation to sleep
at low doses. Overall the effect is similar to that of alcohol. The difference is that
duration is slightly longer and the hangover effects are slightly less and the unpleasant
and dangerous overdose effect of possibly causing temporarily unrousable sleep, or coma,
at high doses. The effects of GHB are heavily affected by one’s body weight, interactions
with other chemicals, and individual reaction. Some people find GHB useful for treating
insomnia, others use it to treat alcoholism. Some use it as a replacement for alcohol. The
effects can be broken down by the dose amount.


Low Dose: .5 to 1.5g
This often causes effects similar to those of 1-3 drinks of alcohol. At this dosage, the
user can fell a mild relaxation, increased sociability, slightly decreased motor skills,
mild dizziness, and other effects similar to mild alcohol intoxication.


Medium Dose: 1-2.5g
This increases the relaxing effects and the physical disequilibrium experienced. Some
report increased appreciation for music, dancing , or talking. Many report positive mood
changes. There is some slurring of speech, silliness, and slight incoherency . Some report
increased feelings of nausea and grogginess. There are some reports of pro-sexual effects,
an increase in tactile sensitivity, relaxation, increased male erectile capacity and
heightened experience of orgasm, although some women report that this is harder to
achieve.


Heavy Dose: 2.5g
A heavy dose can increase feelings of disequilibrium in many people to the point of
feeling very ill. (One reason the GHB has gained notoriety as a Club Drug is that some
people experience extremely positive feelings on Heavy Doses of GHB.) Reports of euphoria,
feeling music deeply, joyous dancing, and other very positive effects are common. An extra
quarter gram can be the difference between euphoria and vomiting.


Overdose: can be little as 2g
One major problem with GHB as an underground recreational substance is that it has a sharp
Continues for 4 more pages >>




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